Background: Urinary tract infections (UTI) are one of the most widespread infectious diseases in hospitalized and outpatients. Empirical therapy of UTI depend on the predictability of the agents causing UTI and knowing their antimicrobial susceptibility patterns.
Objectives: The aim of this study is to investigate the susceptibility pattern of different bacteria species isolated from urinary tract infection to commonly used antimicrobials from Al-Shifa hospital in Gaza strip.
Methodology: A total of 1,276 midstream urine samples from in and out patients suspected of UTI were cultured as per standard urine culture procedures. All positive cultures were tested further to identify isolates using conventional methods. Antimicrobial susceptibility test was performed by the disk diffusion method.
Results: Only 17.2% (219 out of 1.276) of samples were considered positive. The most frequently isolated urinary pathogens were Escherichia coli, Klebsiella spp. High percentage of Gram-negative bacterial isolates was resistant to amoxicillin/clavulanic acid, piperacillin. Gram positive bacterial isolates showed resistance to vancomycin, piperacillin. Of the Gram negative and Gram-positive isolates, 99.5% and 92.3% respectively were multidrug resistant, diversities in MDR patterns were observed among isolates.
Conclusion: Routine surveillance of antibiotic-resistant pattern must be a continuous process so as to provide physicians with up to date information about the local data of UTI antimicrobial resistance.
Keywords: Urinary tract infection, Antimicrobial resistance, and Gaza, Palestine.