Hematological and biochemical study on effect of protective agents against lead toxicity in albino rats

In The present work investigated some parameters in blood serum of albino rats. The daily oral administration of lead acetate at a dose of 20 mg/kg for 20 days caused significant increase in mean corpuscular hemoglobin (MCH) white blood cell count (WBC) and blood platelets (PLT). In contrast significant decrease in red blood cell count (RBC), hemoglobin (HB), hematocrit (HCT),mean corpuscular volume (MCV), mean corpuscular hemoglobin concentrations (MCHC),was recorded during all the experimental periods. In addition, the daily oral administration of lead acetate for 20 days caused general increase of albumin, urea, uric acid , creatinine, cholesterol and triglycerides in rat's blood serum compared to the control level. Moreover, a significant decrease in total protein, globulin, ALT and AST activity was observed after 20 days of lead acetate. Signs of improvements in the previous hematological parameters were noticed after oral administration  and biochemical  of vitamin C or vitamin E with/without zinc sulphate during lead acetate  administration.

Keywords: Lead acetate – vitamin C - vitamin E - hematological and biochemical parameters – albino rats.