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ملخص البحث |
Abstract: Over the past two decades, eleven new antiepileptic drugs (AEDs) have been introduced into the market that expanded treatment options for children with epilepsy. These novel AEDs offer equal efficacy with improved tolerability, pharmacokinetic properties including less drug interactions, and side effect pro?les compared with old drugs. However, despite the wide therapeutic range of old and new AEDs, more than 25% of epileptic patients remain refractory to treatment and thus there is a substantial need to develop more effective drugs that block epileptogenesis, resulting in complete cure of epilepsy. With many new medications available, the clinician treating children with epilepsy must be well versed with the application of these drugs to their patient population. This article will review the mechanisms of action, indications, pharmacokinetics, dosing, and safety profiles of the new AEDs in children with epilepsy. Also, the principles of AED selection for children will be discussed |
