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ملخص البحث |
Abstract: Hematological and biochemical changes were evaluated in sodium fluoride intoxicants in albino rats. The therapeutic action of vitamin C and olive oil was also determined. Sodium Fluoride administration caused significant decrease in blood parameters such as white blood cells count, platelets count and caused a general decrease in red blood cells count, hemoglobin content, hematocrit value, mean corpuscular volume and mean corpuscular hemoglobin. On the other hand oral administration of sodium fluoride to albino rats, caused a general increase in its biochemical parameters such as urea, uric acid, creatinine, cholesterol and triglycerides; while glucose level decreased significantly. Our results indicate a general decrease of total protein and albumin concentrations, while globulin levels increased. Liver function enzymes such as alnine-amino transferase, aspartate amino transferase and alkaline phosphatase and bilirubin levels were increased as well under the influence of sodium fluoride administration. Signs of improvements in the previous hematological and some biochemical parameters were noticed after the administration of vitamin C or olive oil prior to sodium fluoride administration. |
