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ملخص البحث |
Despite the fact that COVID-19 is a respiratory disease, clinical data has shown that COVID-19 is associated with cardiovascular complications. This study aimed to evaluate the effect of SARS-CoV-2 infection on cardiac biomarkers in cardiovascular patients during ICU hospitalization. The study population (n = 60) was divided into three groups: group A (n=20, COVID-19 patients with cardiovascular diseases); group B (n=20, patients with cardiovascular diseases who didn’t have COVID-19); and group C (n=20, COVID-19 patients who didn’t have cardiovascular diseases). The levels of cardiac biomarkers were estimated in the blood samples of each participant. Our findings showed a significant increase in the serum levels of cTnI (pg/dL), CK-MB (mg/dL) and LDH (IU/L) among ICU-hospitalized COVID-19 patients with pre-existing cardiovascular diseases compared with the ICU-hospitalized COVID-19 patients and the ICU-hospitalized patients with cardiovascular diseases (p values: 0.006, 0.004, and 0.0001, respectively). Additionally, we found that group A and group C COVID-19 patients had significantly higher D-dimer levels than group B patients; however, the increase was more evident in COVID-19 patients with pre-existing cardiovascular disorders (p value=0.04). Moreover, the results revealed that SARS-CoV-2 infection significantly increased both PT and PPT values during ICU-hospitalization, and the increase was more marked in patients with pre-existing cardiovascular diseases. Finally, we found that the mortality rate was higher in the patients with severe myocardial injury which was more noticeable in group A, where 13 (65%) of the patients had severe myocardial injury, of whom 9 patients died. In conclusion, these findings suggest that SARS-CoV-2 infection may increase the severity of myocardial injury and the likelihood of death in ICU patients, particularly those with cardiovascular diseases.
Keywords: Myocardial injury, COVID-19, SARS-CoV-2, Cardiac biomarkers
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