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ملخص البحث |
Abstract
We aimed to investigate the effects of weight reduction on body mass index, hemoglobin A1c, insulin, glucose and lipid profile among type 2 diabetic obese females in Gaza strip, Palestine.
This prospective study included 50 obese type 2 diabetic females (30-60 years old) as cases and 50 apparently healthy age-matched females as controls for baseline comparisons. A low-calorie diet (1200–1500 Kcal/day) and a daily aerobic activity program were prescribed to obese diabetic females for 24 successive weeks. The study variables were measured and statistically compared to those of the controls. At baseline, body mass index, hemoglobin A1c, insulin, glucose, and lipid profiles showed significant differences between cases and controls. After 24 weeks of weight reduction program, there were significant decreases in body mass index, hemoglobin A1c percentage, insulin and glucose concentrations in obese diabetic females compared to their baseline levels (P<0.05). Cholesterol, triglyceride, and low-density lipoprotein levels were significantly decreased among obese females with type 2 diabetes after weight reduction program compared to their baseline levels. Following the 24-week weight loss program, BMI in diabetic obese women showed a statistically significant positive correlation with HbA1c levels, insulin, glucose, cholesterol, triglyceride, and LDL-C levels (P<0.01), while HDL-C) concentrations were non-significantly increased. Weight reduction using a low-calorie diet combined with aerobic exercise improves body mass index, hemoglobin A1c, insulin and lipid profile. This weight reduction program is associated with better glycemic control, which may justify a lower antidiabetic dose in obese diabetic females. Such weight reduction may also decrease cardiovascular complications in individuals with type 2 diabetic.
Keywords: Hemoglobin A1c, Insulin, Body-Mass Index, Weight Reduction, Diabetes, Palestinian females
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